Final Fantasy IV Walkthrough

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This guy, like his “brother”, has a lot of nasty surprises. His arsenal is fully loaded. He'll throw out Big Bang every so often, so have your healer at the ready for a quick Curaja. Also out of the gate, he'll transform your party into toads. It may take a turn or two to recover back into human form. Also at his disposal is the single digit HP inducing Whirl, and a very powerful Flare. To add to the carnage, his coupe de grace is dishing out a combination of Earthquake, Lightning, and Flame that'll make your HP vanish in the blink of an eye. On top of that, he'll also send a Tidal Wave – Tornado combo at you as well. When his HP reaches a certain point, he'll begin to assault you 5 times in a row with his physical attack. Most likely you'll need a Phoenix Down to bring the assaulted teammate back to consciousness.
You might want to be careful if you have Palom or Rydia in your party as he'll counter every black magic spell with Reflect, essentially making your black mages unusable (unless you want to use the loophole by using Reflect on a party member and bounce the black magic spell off of them. Or you can use an unreflectable spell like Quake or Meteor). You should prepare for this battle like you did against the original Zeromus. He'll barrage you with a lot of attacks and take away your HP at a high level. You may wish to be stocked up on Phoenix Downs, and all the Megalixirs you've obtained on your trip through the Ruins will prove very useful too.

Your attack strategy will vary depending on who you have in your party. Just keep in mind that the bulk of your offense is going to come from the heavy hitters: Cecil, Yang, Kain, and/or Cid. You might want to be careful when you use Cecil if he is equipped with the Lightbringer. The weapon randomly casts Holy, and even though it's an additional attack, if Zeromus has cast Reflect on himself, the Holy will reflect off of him and smack one of your unfortunate team members.
Kain should continuously jump. If you completed his trial and have Double Jump, that's even better. If you have Yang with you, and if you have completed his trial and have Deadly, use that. If you did not and are still stuck with Power, bypass it and go for a normal physical attack. The damage done by Deadly makes up for the time it takes. Power does not. If Edge is with you, have him throw out everything you have in your inventory. Cid will strike with his powerful hammer. Rosa is obviously your designated healer. Porom is as well, albeit if Palom is with her, and you completed their trial, use their Twin magic and hope for the Double Meteor attack. Rydia is best off using her strongest summon, which hopefully is Bahamut by now.

If you keep the attacks coming consistently and pop Megalixirs and Curaja absolutely whenever needed, Zeromus EG will meet the same fate as his "brother".